
Tetrahedron p. 3931 - 3944 (1987)
Update date:2022-07-30
Topics: Lipase Column chromatography Ester Yield Chiral center Enantiomeric excess (ee) Hydrolysis Enantiomers Optical rotation HPLC (high-performance liquid chromatography) Reaction Monitoring Kinetic Resolution Substrate Specificity Transesterification Enzyme Immobilization Racemic mixture Chiral stationary phase Acyl donor Organic solvent tolerance
Oberhauser, Th.
Bodenteich, M.
Faber, K.
Penn, G.
Griengl, H.
Chiral norbornane-type alcohols of high optical purity were prepared via enzymatic resolution of their racemic esters using lipases from Candida cylindracea and Pseudomonas sp.This method presents a short and efficient access to a number of chiral building blocks on a molar scale for the synthesis of optically active cyclopentane systems.
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