Journal of Organic Chemistry p. 1611 - 1615 (1988)
Update date:2022-07-29
Topics:
Lam, Lister K. P.
Gair, Iain A.
Jones, J. Bryan
Preparative-scale horse liver alcohol dehydrogenase catalyzed reductions of racemic cis and trans bicyclic O- and S-heterocyclic ketones proceed with high enantiomeric selectivity.The diastereotopic selectivity for the pro-R faces of the carbonyl groups is also very high.The ee's of all but one of the product alcohols are >97percent.The ee's of the recovered ketones are in the 52-60percent range.The results confirm that an ether-oxygen or -sulfur substituent does not alter the enzyme's overall structural specificity or stereospecificity toward its ketone substrates.
View MoreXian Changyue Biological Technology Co., Ltd.
website:https://www.xachangyue.com/
Contact:+86-029-88211911
Address:Keji Road NO.70
ZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.
website:http://www.zenvasino.com
Contact:+86-138-72658998
Address:Shibeishan Road,Zhijiang, Hubei, China
Meryer (Shanghai) Chemical Technology Co., Ltd.
website:http://www.meryer.com/cn/index/
Contact:+86-755-86170518
Address:Minhang,Shanghai, China
Shao Xing Empire Import&Export CO.,ltd
Contact:86-575-82127757
Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Doi:10.1002/jhet.1005
(2013)Doi:10.3987/COM-08-S(F)35
(2009)Doi:10.1007/s00706-007-0844-6
(2008)Doi:10.1039/f19827801873
(1982)Doi:10.1016/S0040-4039(00)96293-2
(1987)Doi:10.3987/COM-08-11478
(2009)
