Metallic Base-Induced Cycloadditions of N-(1-Cyanoalkyl)imines via N-Metalated Azomethine Ylides: Enhanced Reactivity and High Regio- and Stereoselectivity

Article abstract of DOI:10.1246/bcsj.60.3359

Lithiation of N-(1-cyanoalkyl)imines with LDA generates new N-lithiated azomethine ylide 1,3-dipoles which show enhanced reactivity toward dipolarophiles.They undergo exclusively regio- and stereoselective 3+2 cycloaddition reaction with α,β-unsaturated e