
Tetrahedron Letters p. 4037 - 4040 (1987)
Update date:2022-07-29
Topics:
Jefford, Charles W.
Jaggi, Danielle
Boukouvalas, John
Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).
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