Rationally designed 4-phenoxy substituted prolinamide phenols organocatalyst for the direct aldol reaction in water

DOI: 10.1016/j.tetlet.2008.10.120

Source and publish data:

Tetrahedron Letters p. 1173 - 1176 (2009)

Update date:2022-08-05

Topics:

Authors:

Zhang, Shu-peng

Fu, Xiang-kai

Fu, Shao-dong

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Article abstract of DOI:10.1016/j.tetlet.2008.10.120

A rationally designed 4-phenoxy substituted prolinamide phenols as an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1), and enantioselectivity (up to 97%) were obtained under optimal condition. The influence of substituent groups on the reactivity of catalysts was studied in detail. Crown Copyright

Full text of DOI:10.1016/j.tetlet.2008.10.120

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