N-PERHALOFLUOROALKYLATION OF SECONDARY AMINES BY THE REACTIONS OF THE AMINES AND AMIDES WITH PERHALOFLUOROALKANES. HALOPHILIC ATTACK OF NITROGEN NUCLEOPHILE ON C-Br BOND.

Article abstract of DOI:10.1016/S0040-4039(00)96359-7

Secondary amines and amides react spontaneously with perhalofluoroalkanes CF₂BrCFBrX(X = F, Cl, CF₃) to afford N-perhalofluoroalkylated tertiary amines in fair to good yields.Evidence for an anionic chain process initiated by the bromophilic attack of nitrogen nucleophiles on C-Br bonds is given.