Total Synthesis of (+)-Lactacystin from D-Glucose

DOI: 10.1039/c39950000793

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 793 - 794 (1995)

Update date:2022-08-05

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Authors:

Chida, Noritaka

Takeoka, Jun

Tsutsumi, Noriko

Ogawa, Seiichiro

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Article abstract of DOI:10.1039/c39950000793

The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor, is described; the γ-lactam portion possessing a quaternary carbon in 1 was constructed stereoselectively from D-glucose using the allylic trichloroac

Full text of DOI:10.1039/c39950000793

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