Bioorganic and Medicinal Chemistry Letters p. 1261 - 1263 (2009)
Update date:2022-08-04
Topics:
Phelan, Ryan M.
Ostermeier, Marc
Townsend, Craig A.
An efficient synthesis of a 5-fluorouracil-cephalosporin prodrug is described for use against colorectal and other cancers in antibody and gene-directed therapies. The compound shows stability in aqueous media until specifically activated by β-lactamase (
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