N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.

DOI: 10.1021/jm00403a004

Source and publish data:

Journal of medicinal chemistry p. 1496 - 1500 (1988)

Update date:2022-07-29

Topics:

Authors:

Focher Focher

Hildebrand

Freese Freese

Ciarrocchi

Noonan Noonan

Sangalli

Brown Brown

Spadari Spadari

Wright Wright

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Article abstract of DOI:10.1021/jm00403a004

A series of N2-substituted guanine derivatives was screened against mammalian thymidine kinase and the thymidine kinase encoded by type I herpes simplex virus to examine their capacity to selectivity inhibit the viral enzyme. Several bases, nucleosides, a

Full text of DOI:10.1021/jm00403a004

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