Synthesis and biological activity of some transition-state inhibitors of human renin

DOI: 10.1021/jm00117a027

Source and publish data:

Journal of Medicinal Chemistry p. 1839 - 1846 (1988)

Update date:2022-08-05

Topics:

Authors:

Buhlmayer

Caselli Caselli

Fuhrer Fuhrer

Goschke Goschke

Rasetti Rasetti

Rueger Rueger

Stanton Stanton

Criscione

Wood Wood

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Article abstract of DOI:10.1021/jm00117a027

A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu-(OH)-Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (Cha-(OH)-Val) was prepared.

Full text of DOI:10.1021/jm00117a027

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