Journal of Medicinal Chemistry p. 1694 - 1697 (1988)
Update date:2022-08-05
Topics:
Wentland
Perni
Dorff
Rake
A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than
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