Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

DOI: 10.1021/jm00117a005

Source and publish data:

Journal of Medicinal Chemistry p. 1694 - 1697 (1988)

Update date:2022-08-05

Topics:

Authors:

Wentland

Perni Perni

Dorff Dorff

Rake Rake

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00117a005

A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than

Full text of DOI:10.1021/jm00117a005

Products guided by the article

Product name:ethyl 2,3,4,5-tetrafluoro-α-<<(2-hydroxy-1,2-dimethylethyl)amino>methylene>-β-oxobenzenepropanoate

Cas No:114636-49-6

R&D Labs maybe for 114636-49-6

Zibo Fuxi'er Chemical Co.,Ltd （Shanxian Fuxi'er Chemical Co.,Ltd）

Contact:+86-533-2091422

Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Hunan Zhongqi Pharmaceutical Co., Ltd

website:http://www.hnzqzy.com

Contact:0730-8722288 13807308622

Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Zhaodu Fine Chemical Plant

Contact:86-310-8067016

Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Jinan Trio PharmaTech Co., Ltd

Contact:86-531-88811783；+(0)13153010282

Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
Wuhan Kemi-Works Chemical Co., Ltd

website:http://www.kemiworks.com

Contact:86-27-85736489

Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China

Relevant to this article

Nickel-catalyzed direct carboxylation of olefins with CO₂: One-pot synthesis of α,β-unsaturated carboxylic acid salts

Doi:10.1002/chem.201405528
(2014)
Transition metal-diene complexes in organic synthesis - 16.¹ Iron-mediated total synthesis of 1-oxygenated carbazole alkaloids

Doi:10.1016/S0040-4020(01)81809-3
(1993)
A CONVENIENT PREPARATIVE METHOD OF CARBOHYDRATE PHOSPHATES WITH BUTYLLITHIUM AND PHOSPHOROCHLORIDATE

Doi:10.1246/cl.1982.1281
(1982)
Facile stereoselective synthesis of 1,3-disubstituted-4-trichloromethyl azetidin-2-ones

Doi:10.1016/j.tetlet.2004.07.047
(2004)
Room temperature dynamic polymers based on Diels-Alder chemistry

Doi:10.1002/chem.200802145
(2009)
Novel Synthesis of the Pyrrolizidine Skeleton by Sulfenocycloamination. Total Synthesis of (+/-)-Retronecine and (+/-)-Turneforcidine

Doi:10.1021/jo00169a005
(1983)

Article Doi