Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

DOI: 10.1021/jm00117a005

Source and publish data:

Journal of Medicinal Chemistry p. 1694 - 1697 (1988)

Update date:2022-08-05

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Authors:

Wentland

Perni Perni

Dorff Dorff

Rake Rake

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Article abstract of DOI:10.1021/jm00117a005

A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than

Full text of DOI:10.1021/jm00117a005

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