A NOVEL INHIBITOR OF HUMAN α-L-FUCOSIDASE: ENANTIOSELECTIVE SYNTHESIS OF L-FUCOAMIDRAZONE

DOI: 10.1016/S0040-4039(00)76682-2

Source and publish data:

Tetrahedron Letters p. 3845 - 3848 (1994)

Update date:2022-08-04

Topics: Synthesis Chromatography Hydrolysis Enantioselective synthesis Inhibitor Spectroscopy Kinetic Analysis Enzyme assay α-l-fucosidase Fucose

Authors:

Schedler, David J. A.

Bowen, Benjamin R.

Ganem, Bruce

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Article abstract of DOI:10.1016/S0040-4039(00)76682-2

A short, chiral synthesis of the title inhibitor 1 is reported from D-galactosamine by chain end interchange.The L-fucoamidrazone is a good competitive inhibitor of human α-L-fucosidase (K_i = 820 nM).

Full text of DOI:10.1016/S0040-4039(00)76682-2

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