Tetrahedron Letters p. 3845 - 3848 (1994)
Update date:2022-08-04
Topics: Synthesis Chromatography Hydrolysis Enantioselective synthesis Inhibitor Spectroscopy Kinetic Analysis Enzyme assay α-l-fucosidase Fucose
Schedler, David J. A.
Bowen, Benjamin R.
Ganem, Bruce
A short, chiral synthesis of the title inhibitor 1 is reported from D-galactosamine by chain end interchange.The L-fucoamidrazone is a good competitive inhibitor of human α-L-fucosidase (Ki = 820 nM).
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