Bioorganic and Medicinal Chemistry Letters p. 1801 - 1806 (1999)
Update date:2022-07-30
Topics:
Keenan, Richard M.
Miller, William H.
Barton, Linda S.
Bondinell, William E.
Cousins, Russell D.
Eppley, Daniel F.
Hwang, Shing-Mei
Kwon, Chet
Lago, M. Amparo
Nguyen, Thomas T.
Smith, Brian R.
Uzinskas, Irene N.
Yuan, Catherine C. K.
A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2-aminopyridine arginine mimetic into the 3- oxo-1,4-benzodiazepine-2-acetic acid integrin antagonist series led to novel and potent nonpeptide vitronectin receptor antagonists with promising levels of oral bioavailability.
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