
Tetrahedron p. 4669 - 4678 (1987)
Update date:2022-07-29
Topics:
Baraldi, P. G.
Barco, A.
Benetti, S.
Pollini, G. P.
Simoni, D.
Zanirato, V.
The compatibility of nitromethane conjugate addition to 2-cyclopentenones bearing a 4-oxygenated function has been illustrated through a short and practical synthesis of the Corey aldehyde, a key intermediate in prostaglandin synthesis, in both racemic and optically active form.A new synthesis of PGF2α featuring the introduction of the ω-chain via <3+2> cycloaddition has been also described.
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