Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-β-D-arabinofuranosyluracil

DOI: 10.1021/jm00403a026

Source and publish data:

Journal of Medicinal Chemistry p. 1642 - 1647 (1988)

Update date:2022-08-04

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Authors:

Matulic-Adamic

Takahashi

Chou Chou

Gadler Gadler

Price Price

Reddy Reddy

Kalman Kalman

Watanabe

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Article abstract of DOI:10.1021/jm00403a026

A new synthesis of 5-(monofluoromethyl)- and 5-(difluoromethyl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyluracil (F-FMAU and F₂-FMAU) is reported. 3',5'-Di-O-(tert-butyldiphenyl)silylated thymidine or FMAU was photochemically brominated with NBS t

Full text of DOI:10.1021/jm00403a026

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