Tetrahedron Letters p. 701 - 704 (1988)
Update date:2022-09-26
Topics:
Harnden, M. R.
Parkin, A.
Wyatt, P. G.
Synthetic approaches to 9-(3-hydroxypropoxy)guanine (2) involving the intermediacy of either a 1-alkoxyimidazole (7) or a 4-alkoxyaminopyrimidine (13) are described.This 9-alkoxyguanine (2) has potent and selective anti-herpesvirus activity and is the first reported member of a new series of antiviral acyclonucleosides.
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