Synthesis of Oligoribonucleotides by Using 2'-O-(1-Methyl-1-methoxy)ethyl Nucleosides

Article abstract of DOI:10.1246/cl.1987.1787

3',5'-O-Tetraisopropyldisiloxanylnucleosides smoothly react with 2-methoxypropene to give 2'-O-(1-methyl-1-methoxy)ethyl nucleosides in high yields without formation of diastereoisomers.These nucleosides were used as intermediates for oligonucleotide synthesis by the phosphotriester method.The (1-methyl-1-methoxy)ethyl group was removed rapidly from oligonucleotides by acid treatment.