Chemistry Letters p. 1787 - 1790 (1987)
Update date:2022-08-05
Topics:
Takaku, Hiroshi
Imai, Kazuaki
Nakayama, Koukichi
3',5'-O-Tetraisopropyldisiloxanylnucleosides smoothly react with 2-methoxypropene to give 2'-O-(1-methyl-1-methoxy)ethyl nucleosides in high yields without formation of diastereoisomers.These nucleosides were used as intermediates for oligonucleotide synthesis by the phosphotriester method.The (1-methyl-1-methoxy)ethyl group was removed rapidly from oligonucleotides by acid treatment.
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Doi:10.1080/00397910802517863
(2009)Doi:10.1016/j.bmcl.2018.02.039
(2018)Doi:10.1007/BF00956378
(1987)Doi:10.1016/j.tet.2017.03.012
(2017)Doi:10.1021/ja01559a049
(1957)Doi:10.1016/S0040-4020(01)90302-3
(1987)
