Regiospecific Reduction of the 2-Carbonyl Group of the 6-Hydroxypyrimidopurine-2,4,8(1H,3H,9H)-trione System by Selected Metal Hydrides. A Novel Reduction of a Fused Xanthine Nucleus

DOI: 10.1021/jo00249a023

Source and publish data:

Journal of Organic Chemistry p. 3265 - 3271 (1988)

Update date:2022-08-03

Topics:

Authors:

Conn, David J.

Kaminski, James J.

Solomon, Daniel M.

McPhail, Andrew T.

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Article abstract of DOI:10.1021/jo00249a023

A series of substituted 6-hydroxypyrimido<2,1-f>purine-2,4,8(1H,3H,9H)-triones 1 have been reduced to the corresponding 2,3-dihydro-6-hydroxypyrimido<2,1-f>purine-4,8(1H,9H)-diones 2 by treatment with excess lithium borohydride in refluxing dioxane or sod

Full text of DOI:10.1021/jo00249a023

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