Regiospecific Reduction of the 2-Carbonyl Group of the 6-Hydroxypyrimidopurine-2,4,8(1H,3H,9H)-trione System by Selected Metal Hydrides. A Novel Reduction of a Fused Xanthine Nucleus

DOI: 10.1021/jo00249a023

Source and publish data:

Journal of Organic Chemistry p. 3265 - 3271 (1988)

Update date:2022-08-03

Topics:

Authors:

Conn, David J.

Kaminski, James J.

Solomon, Daniel M.

McPhail, Andrew T.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00249a023

A series of substituted 6-hydroxypyrimido<2,1-f>purine-2,4,8(1H,3H,9H)-triones 1 have been reduced to the corresponding 2,3-dihydro-6-hydroxypyrimido<2,1-f>purine-4,8(1H,9H)-diones 2 by treatment with excess lithium borohydride in refluxing dioxane or sod

Full text of DOI:10.1021/jo00249a023

Products guided by the article

Product name:9-benzyl-1,3-dimethyl-6-hydroxy-7-(2-hydroxyethyl)pyrimido<2,1-f>purine-4,8(1H,9H)-dione

Cas No:114927-80-9

R&D Labs maybe for 114927-80-9

Jiangsu Hualun Chemical Industry Co., Ltd

website:http://www.hualunchem.com

Contact:+86-0514-86464168 86507985

Address:39# Middle Renmin Road, Dinghuo Town
Anhui Xinyuan Technology Co.,Ltd

Contact:0086-559-3515800

Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Rugao Jinling Chemical Co., Ltd.(expird)

Contact:0086-513-68005586

Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Jinan Hongfangde Pharmatech Co.LTD

Contact:0531-88870908

Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Jilin Tiandicheng Biotech Co.,Ltd

Contact:+86-18103315327

Address:jinlin

Relevant to this article

Oxabenzomorphanes: Synthesis of CNS-effective hexahydro-2,7-methano-1,5-benzoxazonines

Doi:10.1002/ardp.19883210604
(1988)
Cycloaddition reactions of 1-alkyl-3,4,5-triphenyl-1,2-diphosphacyclopenta- 2,4-dienes

Doi:10.1002/ejoc.200801181
(2009)
HIGHLY ENANTIOSELECTIVE SYNTHESES OF α-HYDROXYACIDS USING N-BENZYL-4,4,7α-TRIMETHYL-TRANS-OCTAHYDRO-1,3-BENZOXAZINE AS A CHIRAL ADJUVANT

Doi:10.1016/S0040-4020(01)87677-8
(1987)
Doi:10.1002/ardp.19592920207
(1959)
The influence of substituents at C² carbon atom of thiosemicarbazones {R(H)C²=N³-N²(H)-C ¹(=S)-N¹H₂} on their dentacy in Pt ^II/Pd^II complexes: Synthesis, spectroscopy, and crystal structures

Doi:10.1002/zaac.200700538
(2008)
Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro

Doi:10.1016/j.bmc.2009.02.053
(2009)

Article Doi