Arylpiperazine Derivatives as High-Affinity 5-HT1A Serotonin Ligands

Article abstract of DOI:10.1021/jm00118a018

Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT_1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT_1A sites and/or decrease their affinity for 5