Journal of Medicinal Chemistry p. 2097 - 2102 (1988)
Update date:2022-07-29
Topics:
Anderson, Wayne K.
Heider, Arvela R.
Raju, Natarajan
Yucht, Jeffery A.
A series of bis<<(carbamoyl)oxy>methyl>-substituted pyrrole-fused tricyclic heterocycles were synthesized by using 1,3-dipolar cycloaddition reactions with a trifluoromethanesulfonate salt of an appropriate Resissert compound or with a mesoionic oxazolone intermediate.All of the bis(carbamates) were active in vivo against P388 lymphocytic leukemia with 5,6-dihydro-8-methoxy-1,2-bis(hydroxymethyl)pyrrolo<2,1-a>isoquinoline bis
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