DIFFERENT MODES OF ALKALINE HYDROLYSIS OF FERVENULIN AND ISOFERVENULIN

Article abstract of DOI:10.1007/BF00479380

Unlike rheumycin and fervenulin, isofervenulin and 3-methylisofervenulin are hydrolyzed by aqueous alkalies at the N₍₅₎-C₍₆₎ bond.On acidification of the reaction mixture, the N-carboxy-N-methylcarbamoyltriazines formed are reconverted into the starting isofervenulins, and on basification (pH > 10) into methylaminotriazinecarboxamides.A by-product of the alkaline hydrolysis of isofervenulin is a product of the contraction of the uracil ring, namely imidazotriazinone-7a-carboxylic acid.