
Chemistry of Heterocyclic Compounds p. 1247 - 1251 (1987)
Update date:2022-07-29
Topics:
Shorshnev, S. V.
Esipov, S. E.
Chernyshev, A. I.
Pozharskii, A. F.
Nanavyan, I. M.
Kuz'menko, V. V.
Unlike rheumycin and fervenulin, isofervenulin and 3-methylisofervenulin are hydrolyzed by aqueous alkalies at the N(5)-C(6) bond.On acidification of the reaction mixture, the N-carboxy-N-methylcarbamoyltriazines formed are reconverted into the starting isofervenulins, and on basification (pH > 10) into methylaminotriazinecarboxamides.A by-product of the alkaline hydrolysis of isofervenulin is a product of the contraction of the uracil ring, namely imidazotriazinone-7a-carboxylic acid.
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