Reduction of Lactams and Thiolactams by Sodium Borohydride: Application in the Synthesis of Some Alkaloids

DOI: 10.1021/jo00253a014

Source and publish data:

Journal of Organic Chemistry p. 4236 - 4241 (1988)

Update date:2022-07-30

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Authors:

Mandal, S. B.

Giri, V. S.

Sabeena, M. S.

Pakrashi, S. C.

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Article abstract of DOI:10.1021/jo00253a014

Lactams 1a-8a and thiolactams 1b-8b,9a,10b-12b and 13 could be reduced to their corresponding amines in 70-98percent yield by using borohydide-tert-butyl alcohol-methanol mixtures under reflux.Even the vinylogous amide 19 underwent reduction to afford dep

Full text of DOI:10.1021/jo00253a014

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