Enantioselective Synthesis of the 1β-Methylcarbapenems via Cycloaddition of 3-Siloxypentadiene and 4-Acetoxyazetidinone

DOI: 10.1021/jo00252a067

Source and publish data:

Journal of Organic Chemistry p. 4154 - 4156 (1988)

Update date:2022-08-05

Topics:

Authors:

Sowin, Thomas J.

Meyers, A. I.

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Article abstract of DOI:10.1021/jo00252a067

The cycloaddition of a 3-siloxy-1,3-pentadiene and the 4-acetoxyazetidinone 3 followed by ring contraction and phosphorylation leads to the key precursor of 1β-methylcarbapenems (11) in a five-step process in 27percent overall yield.

Full text of DOI:10.1021/jo00252a067

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Product name:2-{(2S,3S)-1-Benzyloxycarbonylmethyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionic acid

Cas No:115827-69-5

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