Bioorganic and Medicinal Chemistry Letters p. 5289 - 5292 (2009)
Update date:2022-08-04
Topics:
Mehlmann, John F.
Crawley, Matthew L.
Lundquist IV, Joseph T.
Unwalla, Ray J.
Harnish, Douglas C.
Evans, Mark J.
Kim, Callain Y.
Wrobel, Jay E.
Mahaney, Paige E.
Pyrrole[2,3-d]azepines have been identified as potent agonists of the farnesoid X receptor (FXR). Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds were de
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