Synthesis of chiral and achiral pyranenamine derivatives. Potent agents with topical ocular antiallergic activity

Article abstract of DOI:10.1021/jm00105a060

The SS, RR and meso stereoisomers of pyranenamine SK and F 84210 (2) were synthesized stereospecifically starting from commercially available (R)-(-)- or (S)-(+)-2,2-dimethyl-1,3-dioxolane-4-methanol (3). In addition, two achiral pyranenamines 19 and 26 w