Antiinflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl)phenols

DOI: 10.1021/jm00121a021

Source and publish data:

Journal of Medicinal Chemistry p. 100 - 104 (1989)

Update date:2022-08-03

Topics:

Authors:

Lazer, Edward S.

Wong, Hin-Chor

Possanza, Genus J.

Graham, Anne G.

Farina, Peter R.

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Article abstract of DOI:10.1021/jm00121a021

A series of 2,6-di-tert-butyl-4-(2-arylethenyl)phenols was prepared and examined for their ability to inhibit cyclooxygenase and 5-lipoxygenase in vitro and developing adjuvant arthritis in vivo in the rat.Structure-activity relationships are discussed.Am

Full text of DOI:10.1021/jm00121a021

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