Efficient methods for the preparation of acetylenic ketones

Article abstract of DOI:10.1016/0022-328X(88)80002-0

A number of acetylenic ketones RC<*>CC(=O)R' have been obtained in good yields from lithiated acetylenes RC<*>CLi and acetic anhydride, N,N-dimethylacetamide, or N,N-dimethylbenzamide.The most convenient and general method consists of treating alkynylzinc chlorides with acid halides R'C(=O)Cl.Benzoyl chloride (R'=Ph), acryloyl chloride (R'=CH2=CH) and butynoyl chloride (R'=C2H5C<*>C) react only in the presence of a catalytic amount of Pd4.