Chemical and Pharmaceutical Bulletin p. 797 - 817 (1995)
Update date:2022-08-04
Topics:
Kobayashi
Inoue
Nishino
Fujihara
Oizumi
Kimura
Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.
View MoreContact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
zhangjiagang vinsce bio-pharm limited.
Contact:0512-56362800
Address:Buillding D.N0.7guangdong road.Free Trad Zone,Zhangjiagang
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
website:https://sdjingyuan.lookchem.com/
Contact:86-531-82687998
Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China
Contact:+86 18616952870
Address:Area
Doi:10.1016/S0040-4039(00)80176-8
(1988)Doi:10.1016/j.jorganchem.2016.12.008
(2017)Doi:10.1016/S0040-4020(01)80085-5
(1989)Doi:10.1021/jo900246z
(2009)Doi:10.1039/b902556a
(2009)Doi:10.1016/j.mencom.2008.11.015
(2008)
