Highly diastereoselective approach to novel phenylindolizidinols via benzothieno analogues of tylophorine based on reductive desulfurization of benzo[b]thiophene

Article abstract of DOI:10.1016/j.tetasy.2009.02.042

Chiral tetra- and hexahydro[1]benzothieno[2,3-f]indolizines 3-5, 9, and 11 were synthesized easily from benzo[b]thiophene-2-carboxaldehyde (1) and (S)-glutamic acid (2) in good overall yields and both high enantio- and diastereomeric purities. Applying a