Design and synthesis of novel pinacolylboronate containing combretastatin 'antimitotic agent' analogues

Article abstract of DOI:10.1016/j.tetlet.2009.04.003

We developed a procedure to synthesize pinacolyl boronate containing stilbene derivatives and used this procedure to synthesize boron-containing combretastatin analogues. The key step involves the Wittig reaction of the ylide 4-(4,4,5,5-tetramethyl-1,3,2-