ASYMMETRIC ALDOL REACTION OF α-ISOCYANOCARBOXYLATES WITH PARAFORMALDEHYDE CATALYZED BY CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEXES: CATALYTIC ASYMMETRIC SYNTHESIS OF α-ALKYLSERINES

DOI: 10.1016/S0040-4039(00)80063-5

Source and publish data:

Tetrahedron Letters p. 235 - 238 (1988)

Update date:2022-09-26

Topics:

Authors:

Ito, Yoshihiko

Sawamura, Masaya

Shirakawa, Eiji

Hayashizaki, Keiichi

Hayashi, Tamio

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Article abstract of DOI:10.1016/S0040-4039(00)80063-5

Aldol reaction of methyl α-isocyanocarboxylates (CNCH(R)COOMe: R=H, Me, Et, i-Pr, Ph) with paraformaldehyde in the presence of 1 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) complex gave optically active 4-alkyl-2-oxazoline-4-carboxylates (up to 83percent ee) which were readily hydrolyzed to α-alkylserines.

Full text of DOI:10.1016/S0040-4039(00)80063-5

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