Design and synthesis of DNA cleaving bleomycin models: 1,2-trans- disubstituted cyclopropane units as novel linkers

DOI: 10.1016/S0040-4039(00)73490-3

Source and publish data:

Tetrahedron Letters p. 5323 - 5326 (1994)

Update date:2022-08-05

Topics:

Authors:

Huang Huang

Quada Jr.

Lown Lown

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Article abstract of DOI:10.1016/S0040-4039(00)73490-3

The design and synthesis of 1a - e, functional models for bleomycin are described in which AMPHIS, a metal-complexing model of bleomycin, and a distamycin moiety are connected with a series of linkers. Studies on the rates of DNA breakage and a mobility a

Full text of DOI:10.1016/S0040-4039(00)73490-3

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