Design and synthesis of DNA cleaving bleomycin models: 1,2-trans- disubstituted cyclopropane units as novel linkers

Article abstract of DOI:10.1016/S0040-4039(00)73490-3

The design and synthesis of 1a - e, functional models for bleomycin are described in which AMPHIS, a metal-complexing model of bleomycin, and a distamycin moiety are connected with a series of linkers. Studies on the rates of DNA breakage and a mobility a