Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

DOI: 10.1021/jo00261a010

Source and publish data:

Journal of Organic Chemistry p. 6042 - 6047 (1988)

Update date:2022-08-05

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Authors:

Lee, Ho H.

Palmer, Brian D.

Denny, William A.

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Article abstract of DOI:10.1021/jo00261a010

The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of

Full text of DOI:10.1021/jo00261a010

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