Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

DOI: 10.1021/jo00261a010

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Journal of Organic Chemistry p. 6042 - 6047 (1988)

Update date:2022-08-05

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Authors:

Lee, Ho H.

Palmer, Brian D.

Denny, William A.

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Article abstract of DOI:10.1021/jo00261a010

The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of

Full text of DOI:10.1021/jo00261a010

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Article Doi

Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

DOI: 10.1021/jo00261a010

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jo00261a010

Full text of DOI:10.1021/jo00261a010

Products guided by the article

R&D Labs maybe for 117252-54-7

Relevant to this article

Gold-catalyzed intramolecular allylic amination of 2-tosylaminophenylprop- 1-en-3-ols. A concise synthesis of (±)-angustureine

The synthesis and some application of new 1,3-dilithiopropanes: dimethylbis(α-lithiobenzyl)silane and its germanium analogue

Cooperativity in multiply H-bonded complexes

Enantioselective michael reactions of β, β-disubstituted nitroalkenes: a new approach to β2,2-amino acids with hetero-quaternary stereocenters

Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal–epithelial transition factor (c-Met) protein kinase

Enantioselective organocatalytic domino oxa-michael/aldol/ hemiacetalization: Synthesis of polysubstituted furofuranes containing four stereocenters

Enantioselective michael reactions of β, β-disubstituted nitroalkenes: a new approach to β^2,2-amino acids with hetero-quaternary stereocenters