Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

DOI: 10.1021/jo00261a010

Source and publish data:

Journal of Organic Chemistry p. 6042 - 6047 (1988)

Update date:2022-08-05

Topics:

Authors:

Lee, Ho H.

Palmer, Brian D.

Denny, William A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00261a010

The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of

Full text of DOI:10.1021/jo00261a010

Products guided by the article

Product name:4-[(E)-Acridin-9-ylimino]-5-methoxy-2-methylsulfanyl-cyclohexa-2,5-dienone

Cas No:117252-54-7

R&D Labs maybe for 117252-54-7

Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd

Contact:0086-10-64430626

Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Shanghai Dianyang Industry Co.,ltd

Contact:+86 21 6492 4669

Address:Chejing RD, Songjiang District, Shanghai, China
China Synchem Technology Co.,Ltd

website:http://www.cnsynchem.com

Contact:+86-0552-4929311

Address:No.217 Daqing Road
Jiangsu Wanlong Chemical Co., Ltd.

website:http://www.wanlongchem.com

Contact:+86-511-86810993 0086-511-8681 0888;

Address:Quanzhou Town, Danyang City, Jiangsu
Jiangsu Willing Bio-Tech Co ltd

website:http://www.willingbio.com/

Contact:+86 18796908173

Address:No 18 Guoqiao Road

Relevant to this article

Gold-catalyzed intramolecular allylic amination of 2-tosylaminophenylprop- 1-en-3-ols. A concise synthesis of (±)-angustureine

Doi:10.1021/jo900917q
(2009)
The synthesis and some application of new 1,3-dilithiopropanes: dimethylbis(α-lithiobenzyl)silane and its germanium analogue

Doi:10.1016/0022-328X(88)80498-4
(1988)
Cooperativity in multiply H-bonded complexes

Doi:10.1039/b908010d
(2009)
Enantioselective michael reactions of β, β-disubstituted nitroalkenes: a new approach to β^2,2-amino acids with hetero-quaternary stereocenters

Doi:10.1021/ol901572x
(2009)
Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal–epithelial transition factor (c-Met) protein kinase

Doi:10.1016/j.bmc.2016.07.019
(2016)
Enantioselective organocatalytic domino oxa-michael/aldol/ hemiacetalization: Synthesis of polysubstituted furofuranes containing four stereocenters

Doi:10.1002/anie.200901333
()

Article Doi