Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

DOI: 10.1021/jo00261a010

Source and publish data:

Journal of Organic Chemistry p. 6042 - 6047 (1988)

Update date:2022-08-05

Topics:

Authors:

Lee, Ho H.

Palmer, Brian D.

Denny, William A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00261a010

The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of

Full text of DOI:10.1021/jo00261a010

Products guided by the article

Product name:4-[(E)-Acridin-9-ylimino]-5-methoxy-2-methylsulfanyl-cyclohexa-2,5-dienone

Cas No:117252-54-7

R&D Labs maybe for 117252-54-7

Jiaxing Anrui Material Technology Co., Ltd.

Contact:86-573-82651652 13305832579

Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
Naturalin Bio-Resource Co., Ltd

website:http://www.naturalin.com

Contact:+86-0731-84430651

Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Shanghai Sunwise Chemical Co., Ltd

website:http://www.sunwisechem.com

Contact:86-021-33883180

Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Beijing Chemdow Co., Ltd

website:http://www.chemdow.com

Contact:0086-10-82435335

Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Weifang Jahwa Chemical Co.,Ltd

Contact:0086-536-8897731,8897730

Address:No.5166 East Dongfeng Street,Weifang,Shandong,China

Relevant to this article

Gold-catalyzed intramolecular allylic amination of 2-tosylaminophenylprop- 1-en-3-ols. A concise synthesis of (±)-angustureine

Doi:10.1021/jo900917q
(2009)
The synthesis and some application of new 1,3-dilithiopropanes: dimethylbis(α-lithiobenzyl)silane and its germanium analogue

Doi:10.1016/0022-328X(88)80498-4
(1988)
Cooperativity in multiply H-bonded complexes

Doi:10.1039/b908010d
(2009)
Enantioselective michael reactions of β, β-disubstituted nitroalkenes: a new approach to β^2,2-amino acids with hetero-quaternary stereocenters

Doi:10.1021/ol901572x
(2009)
Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal–epithelial transition factor (c-Met) protein kinase

Doi:10.1016/j.bmc.2016.07.019
(2016)
Enantioselective organocatalytic domino oxa-michael/aldol/ hemiacetalization: Synthesis of polysubstituted furofuranes containing four stereocenters

Doi:10.1002/anie.200901333
()

Article Doi