Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis

DOI: 10.1021/jo900768c

Source and publish data:

Journal of Organic Chemistry p. 5297 - 5303 (2009)

Update date:2022-07-29

Topics:

Authors:

Zhao, Yujie

Bacher, Adelbert

Illarionov, Boris

Fischer, Markus

Georg, Gunda

Ye, Qi-Zhuang

Fanwick, Phillip E.

Franzblau, Scott G.

Wan, Baojie

Cushman, Mark

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Article abstract of DOI:10.1021/jo900768c

(Chemical Equation Presented) A high-throughput screening (HTS) hit compound displayed moderate inhibition of Mycobacterium tuberculosis and Escherichia coli riboflavin synthases. The structure of the hit compound provided by the commercial vendor was rea

Full text of DOI:10.1021/jo900768c

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Product name:[3-(4-chlorophenyl)-5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl](o-tolyl)methanone

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