Heterocyclic Communications p. 233 - 236 (2008)
Update date:2022-07-30
Topics:
Botsi, Sofia
Tsolomiti, Georgia
Hamilakis, Stylianos
Tsolomitis, Athanase
An asymmetric synthesis of 2-Substituted 3-amino-4-cyanopyrroles via a two-step procedure consisting of a nucleophilic vinylic substitution (S NV), of ethoxymethylenemalononitrile (EMM), with optically pure α-amino acid esters, resulting to the corresponding aminomethylemalononitriles, followed by a Thorpe-Ziegler cyclization, is described.
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