STEREOSPECIFIC SYNTHESIS OF (-)-CARBOCYCLIC 2',3'-DIDEOXYTHYMIDINE, A POTENTIAL ANTI-AIDS AGENT

Article abstract of DOI:10.1016/0040-4039(88)85259-6

The stereospecific synthesis of the title compound (-)-13 is described from the unsaturated bicyclic lactone (+)-1 via a versatile synthetic precursor (12) of carba-2',3'-dideoxynucleosides.The key step of the procedure is the regio- and stereoselective hydroxylation of (+)-1.