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2'-Deoxy-2'-fluoro-ara-Aristeromycin, a New Anti-herpes Agent: the First Direct Introduction of a 2'-Fluoro Substituent into a Carbocyclic Nucleoside

DOI: 10.1039/c39880000898

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 898 - 900 (1988)

Update date:2022-08-02

Topics: Carbocyclic Nucleoside  

Authors:

Biggadike, KeithBiggadike, Keith

Borthwick, Alan D.Borthwick, Alan D.

Exall, Anne M.Exall, Anne M.

Kirk, Barrie E.Kirk, Barrie E.

Ward, Richard A.Ward, Richard A.

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Article abstract of DOI:10.1039/c39880000898

Aristeromycin has been converted in four stages into its 2'-deoxy-2'-fluoro-ara-analogue (4); compound (4) displayed potent anti-herpes activity both in vitro and in vivo.

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