Synthesis and Radical Cyclization of 2-(β-Haloacyl)-1,2-dihydroisoquinolines by Means of Tin Hydride. One-Pot Synthesis of Benzoindolizidine Systems from Isoquinolines

DOI: 10.1246/cl.1988.913

Source and publish data:

Chemistry Letters p. 913 - 916 (1988)

Update date:2022-09-26

Topics:

Authors:

Yamaguchi, Ryohei

Hamasaki, Takashi

Utimoto, Kiitiro

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Article abstract of DOI:10.1246/cl.1988.913

Reactions of isoquinolines activated by 2-halopropionyl chlorides with tributyltin hydride afford selectively 2-(2-halopropionyl)-1,2-dihydroisoquinolines in good yields, the radical cyclizations of which furnish benzoindolizidine systems.The above two

Full text of DOI:10.1246/cl.1988.913

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