Synthesis and Radical Cyclization of 2-(β-Haloacyl)-1,2-dihydroisoquinolines by Means of Tin Hydride. One-Pot Synthesis of Benzoindolizidine Systems from Isoquinolines

Article abstract of DOI:10.1246/cl.1988.913

Reactions of isoquinolines activated by 2-halopropionyl chlorides with tributyltin hydride afford selectively 2-(2-halopropionyl)-1,2-dihydroisoquinolines in good yields, the radical cyclizations of which furnish benzoindolizidine systems.The above two