Synthesis of gastrin antagonists, analogues of the C-terminal tetrapeptide of gastrin, by introduction of a β-homo residue

Article abstract of DOI:10.1021/jm00123a003

A series of analogues of Boc-Trp-Leu-Asp-Phe-NH₂, a potent gastrin agonist, were synthesized by introducing a β-homo residue in the sequence. These compounds were tested in vivo on acid secretion, in the anesthetized rat, and for their ability