ACS Medicinal Chemistry Letters p. 809 - 813 (2011)
Update date:2022-09-26
Topics:
Liu, Kevin K.-C.
Zhu, Jinjiang
Smith, Graham L.
Yin, Min-Jean
Bailey, Simon
Chen, Jeffrey H.
Hu, Qiyue
Huang, Qinhua
Li, Chunze
Li, Qing J.
Marx, Matthew A.
Paderes, Genevieve
Richardson, Paul F.
Sach, Neal W.
Walls, Marlena
Wells, Peter A.
Zou, Aihua
Highly selective PI3K inhibitors with subnanomolar PI3Kα potency and greater than 7000-fold selectivity against mTOR kinase were discovered through structure-based drug design (SBDD). These tetra-substituted thiophenes were also demonstrated to have good
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