REACTIONS ON SOLID SUPPORTS PART IV: REACTIONS OF αβ-UNSATURATED CARBONYL COMPOUNDS WITH INDOLES USING CLAY AS CATALYST

Article abstract of DOI:10.1016/S0040-4039(00)86116-X

Indoles react with αβ-unsaturated carbonyl compounds in the presence of clay catalysts to give substituted indoles in good yields; in one case a 3-benzyl substituent already present migrated to the 2-position, being displaced by the incoming electrophile, thus confirming that electrophilic substitution in indole occurs primarily at the 3-position.