
Tetrahedron p. 11061 - 11068 (1997)
Update date:2022-08-03
Topics:
McDonald, Frank E.
Zhu, Hugh Y. H.
The tungsten pentacarbonyl-induced cyclization of an acyclic alkynol substrate bearing protected oxygen and nitrogen functional groups provides the cyclic tungsten oxacarbene, which is readily converted into a pyranose glycal structurally related to the carbohydrate moieties of the pluramycin and vancomycin families of antitumor antibiotics. In addition a molybdenum-catalyzed cycloisomerization procedure provides an alternative route to this pyranose glycal.
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