Diphenylprolinol silyl ether as a catalyst in an asymmetric, catalytic, and direct michael reaction of nitroethanol with α,β-unsaturated aldehydes

Article abstract of DOI:10.1021/ol901483x

Diphenylprollnol silyl ether was found to be an effective organocatalyst in the enantioselective and direct Michael reaction of nitroethanol and α,β-unsaturated aldehydes, affording the 1-hydroxy-trans-3,4- disubstituted tetrahydropyrans after isomerizatl