Journal of Medicinal Chemistry p. 227 - 234 (1991)
Update date:2022-08-05
Topics:
Rosowsky
Forsch
Moran
Freisheim
The previously undescribed 2-desamino and 2-desamino-2-methyl analogues of aminopterin (AMT) and methotrexate (MTX) were synthesized from 2-amino-5-(chloromethyl)pyrazine-3- carbonitrile. The AMT analogues were obtained via a three-step sequence consistin
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