A modular rearrangement approach toward medicinally relevant phosphinic structures

Article abstract of DOI:10.1021/ol902004p

An unprecedented coupling of a P - C and a C - C bond-forming event In a practical operation was developed to access medicinally relevant phosphinic structures. The strategy relies on an Ireland-Claisen rearrangement triggered by the phospha-Michael addition of silyl phosphonltes to allyl acrylates. This protocol was extended to a more versatile three-component variant that utilizes phosphinic acids, acryloyl chlorides, and allylic alcohols as starting materials.