Further studies on arylpiperazinyl alkyl pyridazinones: Discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain

Article abstract of DOI:10.1021/jm900458r

A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were synthesized and tested icv in a model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a, whi