The Role of the 2-Methyl Substituent in Governing Stereoselective Formation of the E Isomer in the Synthesis of 4-Hydroxy-2-methyltamoxifen (1-phenyl>-1-(4-hydroxy-2-methylphenyl)-2-phenylbut-1-ene)

DOI: 10.1039/P29880001201

Source and publish data:

Journal of the Chemical Society. Perkin transactions II p. 1201 - 1208 (1988)

Update date:2022-08-05

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Authors:

McCague, Raymond

Leung, On-Tai

Jarman, Michael

Kuroda, Reiko

Neidle, Stephen

Webster, Gordon

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Article abstract of DOI:10.1039/P29880001201

Syntheses of 4-hydroxy-2-methyltamoxifen (1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxy-2-methylphenyl)-2-phenylbut-1-ene) by dehydration of diastereoisomeric triphenylbutan-1-ol precursors were compared.Crystal structures of these diastereoisomers h

Full text of DOI:10.1039/P29880001201

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