LEUCOCYANIDIN: SYNTHESIS AND PROPERTIES OF (2R,3S,4R)-(+)-3,4,5,7,3',4'-HEXAHYDROXYFLAVAN

Article abstract of DOI:10.1016/0031-9422(80)85075-8

An isomer of leucocyanidin, (2R,3S,4R)-(+)-3,4,5,7,3',4'-hexahydroxyflavan has been synthesized from (+)-taxifolin, isolated in its phenolic form, and characterized by 1H and 13C NMR, and formation of the 5,7,3',4'-tetramethyl ether.Leucocyanidin readily polymerizes in acid solution to form a procyanidin polymer of high MW. - Key Word Index: Leucocyanidin; flavan-3,4-diols; synthesis; polymerization; phytochemical significance.