General Synthesis of Polyfunctionalized Fluoromethyleneketone Retroamides as Potential Inhibitors of Thrombin

DOI: 10.1016/0040-4039(91)80491-N

Source and publish data:

Tetrahedron Letters p. 7255 - 7258 (1991)

Update date:2022-09-26

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Authors:

Altenburger, J. M.

Schirlin, D.

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Article abstract of DOI:10.1016/0040-4039(91)80491-N

Synthesis of polyfunctionalized fluoromethyleneketone retroamides is described.A potential inhibitor of human Thrombin has been prepared through a Reformatsky type condensation from N-protected p-NO2 phenylalaninal.The reaction conditions are applicable t

Full text of DOI:10.1016/0040-4039(91)80491-N

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