Enantioselective synthesis of planar-chiral phosphines with 1,n-dioxa[n]paracyclophane scaffold and their application as chiral ligands

Article abstract of DOI:10.3987/COM-13-S(S)105

A new family of chiral phosphines based on planar-chiral 1,n-dioxa[n]paracyclophane scaffold was created. They were synthesized with excellent enantioselectivity via asymmetric ortho-lithiation using sec-butyllithium and (-)-sparteine. These phosphines were used as chiral ligands in three reactions: Ag-catalyzed allylation of imines, Pd-catalyzed asymmetric Sonogashira coupling of diiodoparacyclophanes, and Pd-catalyzed asymmetric Suzuki-Miyaura coupling of tricarbonyl(η⁶-ortho-dichlorobenzene)chromium.

Full text of DOI:10.3987/COM-13-S(S)105

HETEROCYCLES, Vol. 88, No. 2, 2014
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HETEROCYCLES, Vol. 88, No. 2, 2014, pp. 1355 - 1370. © 2014 The Japan Institute of Heterocyclic Chemistry
Received, 31st July, 2013, Accepted, 2nd September, 2013, Published online, 11th September, 2013
DOI: 10.3987/COM-13-S(S)105
ENANTIOSELECTIVE SYNTHESIS OF PLANAR-CHIRAL
PHOSPHINES WITH 1,N-DIOXA[N]PARACYCLOPHANE SCAFFOLD
AND THEIR APPLICATION AS CHIRALLIGANDS
Kazumasa Kanda,1 Shoya Oshima,1 Tsubasa Shizuno,1 Risa Hamanaka,1
Miku Fukai,1 and Takanori Shibata1,2*
1 Department of Chemistry and Biochemistry, School of Advanced Science and
Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555, Japan;
2
JST, ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan; E-mail:
tshibata@waseda.jp
Dedicated to Professor Victor Snieckus on the occasion of his 77thbirthday.
Abstract – A new family of chiral phosphines based on planar-chiral
1,n-dioxa[n]paracyclophane scaffold was created. They were synthesized with
excellent enantioselectivity via asymmetric ortho-lithiation using sec-butyllithium
and (-)-sparteine. These phosphines were used as chiral ligands in three reactions:
Ag-catalyzed allylation of imines, Pd-catalyzed asymmetric Sonogashira coupling
of diiodoparacyclophanes, and Pd-catalyzed asymmetric Suzuki-Miyaura
coupling of tricarbonyl(!6-ortho-dichlorobenzene)chromium.
INTRODUCTION
Asymmetric catalysis is a powerful tool for the preparation of enantiomerically enriched compounds.1
Especially, chiral phosphines have shown great ability as efficient ligands, which induce high
enantioselectivity in a number of transition-metal-catalyzed reactions such as asymmetric hydrogenation,
conjugate addition, cross coupling and cycloaddition.1,2 Many of these chiral ligands contain some
common backbones, such as binaphthyl, ferrocenyl, and spirocyclic systems. If a new chiral backbone is
created, new and/or high selectivity, which cannot be achieved by conventional chiral ligands, would be
expected. In this regard, planar-chiral paracyclophane structure is an attractive chiral framework.3,4

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Actually, several [2.2]paracyclophane-based chiral ligands have been reported.5,6 Especially,
4,12-bis(diarylphosphino)[2.2]paracyclophanes (PHANEPHOS derivatives) are commercially available
and realized higher enantioselectivity than other common chiral diphosphine ligands, such as BINAP
derivatives in some reactions.7 But the enantioselective preparation of chiral [2.2]paracyclophane
derivatives is still difficult. In many cases, individual and ingenious resolution procedures are necessary
for racemic compounds.5,6,8 A few protocols of other planar-chiral paracyclophane synthesis was
reported,4,9,10 however, their application for the synthesis of phosphine ligands is difficult. To the best of
our knowledge, there is no phosphine ligand with planar-chiral paracyclophane scaffold other than
[2.2]paracyclophane derivatives. Recently, we reported a new strategy for the planer-chiral
paracyclophane synthesis: enantioselective ortho-lithiation of unflippable 1,n-dioxa[n]paracyclophanes (n
" 11)ꢀusing sec-butyllithium and (-)-sparteine at -78 °C and further lithiation at -20 °C gave planar-chiral
monolithiated and C2-symmetric dilithiated paracyclophanes, respectively. Subsequent treatment of these
chiral lithium salts with various electrophiles gave planar-chiral mono- and disubstituted paracyclophanes
with excellent to almost perfect ee (Scheme 1).11
We considered that this protocol can be used for the synthesis of planar-chiral phosphine derivatives. In
this paper, a new family of planar-chiral phosphines with a 1,n-dioxa[n]paracyclophane backbone was
synthesized by this method and used as chiral ligands in Ag-catalyzed asymmetric allylation,
Pd-catalyzed Sonogashira, and Suzuki-Miyaura couplings.

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RESULTS AND DISCUSSION
Each of 1,n-Dioxa[n]paracyclophanes 1a (n=10) and 1b (n=11) possesses an unflippable ansa chain,12,13
therefore, their mono-substitution on the benzene ring generates planar chirality (Table 1). The reaction of
1a and 1b with sec-butyllithium and (-)-sparteine at -78 °C in diethyl ether followed by treatment with
chlorodiphenylphosphine gave planar-chiral diphenylphosphinoparacyclophanes 2a and 2b with excellent
ee (Entries 1 and 2).14 The structure of 2b was determined by X-ray analysis and its ORTEP diagram was
shown in Figure 1. Treatment of monolithiated 1b with chlorobis(3,5-bis(trifluoromethyl)phenyl)-
phosphine gave corresponding electron-deficient phosphine 2c (Entry 3). Furthermore, planar-chiral
phosphine with (1.4)naphthalenophane skeleton was obtained with excellent ee from 1c (Entry 4).
Table 1. Enantioselective synthesis of planar-chiral monophosphine
Entry
Substrate
X / equiv
1.2
Ar
C6H5
Yield / %
42 (2a)
58 (2b)
41 (2c)
Ee / %
99
1
2
3
4
1a
1b
1b
1c
2.0
C6H5
98
2.0
3,5-(CF3)2C6H3
C6H5
98
98b
1.2
85 (2d)a
a NMR yield. b Phosphine 2d was characterized as the corresponding phosphine
oxide, because 2d could not be separated from 1c.
Figure 1. Thermal ellipsoid plot of 2b is shown at the 30% probability level. The hydrogen atoms and
one part of disorders on the ansa chain were omitted for clarity.

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We also synthesized C2 symmetric planar-chiral diphosphines (Table 2). After the first enantioselective
lithiation of 1a and 1b, further addition of two equivalent amounts of sec-butyllithium at -20°C induced
the second lithiation. Treatment of the obtained dilithiated compounds with excess amounts of
chlorodiphenylphosphine gave the corresponding diphosphines 3a and 3b with almost perfect ee (Entries
1 and 2). The preparation of electron-deficient diphosphine 3c was also possible (Entry 3).
Table 2. Enantioselective synthesis of C2 symmetric planar-chiral diphosphines
Entry
Substrate
Ar
C6H5
Yield / %
55 (3a)
55 (3b)
54 (3c)
Ee / %
98a
99a
1
2
3
1a
1b
1b
C6H5
3,5-(CF3)2C6H3
98a
a Ee was determined as the corresponding diphosphine oxide.
Next we considered the use of the obtained mono- and diphosphines as chiral ligands in
transition-metal-catalyzed reactions and paid attention to the similarity as P,O-ligands between our
developed phosphines and 2-(diphenylphosphino)-2'-methoxy-1,1'-binaphthyl (MOP). We first chose
Ag-catalyzed enantioselective allylation of imines with allylsilanes, where MOP was the preferable ligand
(Table 3).15 We used N-benzylidene-2-methoxyaniline (4a), which was a good substrate in the literature,15
and we examined asymmetric Ag-catalyzed allylation using monophosphines 2a, 2b and diphosphines 3a,
3b, but both of the yield and ee were low in all cases (Entries 1-4).16 In contrast, the reaction of
N-benzylideneaniline (4b) smoothly proceeded and chiral homoallyl amine 5b was obtained in good yield
with moderate ee (Entries 5-8). These results suggest that our developed planar-chiral phosphines could
be used as chiral ligands and show the different selectivity with conventional ligands.

HETEROCYCLES, Vol. 88, No. 2, 2014
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Table 3. Ag-catalyzed allylation of imines using paracyclophane-based phosphine ligands
Entry
Imine
4a
Ligand
2a
Yield / %
5 (5a)
Ee / %
11
1
2
3
4
5
6
7
8
4a
2b
22 (5a)
10 (5a)
11 (5a)
90 (5b)
89 (5b)
89 (5b)
62 (5b)
15
4a
3a
10
4a
3b
38
4b
2a
51
4b
2b
57
4b
3a
48
4b
3b
59
Next we focused attention on the planar chirality of our ligands. One of the typical chiral phosphine
ligands with planar chirality is a ferrocenyl ligand, and various types of chiral ligands are now
commercially available. We also used a ferrocenyl phosphine ligand, (RP)-1-[(R)-!-(dimethylamino)-2-
(diphenylphosphino)benzyl]-2-diphenylphosphinoferrocene (TANIAPHOS) as the best ligand in the
Pd-catalyzed asymmetric double Sonogashira coupling of diiodoparacyclophanes possessing a flippable
ansa chain.10c Based on this background, we chose the asymmetric Sonogashira coupling as the second
model reaction. Under the optimal reaction conditions, the coupling of diiodoparacyclophane 6a with
4-ethynylanisole (7a) gave dialkynylated product 8aa with 57% ee in the presence of cesium carbonate as
a base (Table 4, Entry 1). When organic base such as diisopropylamine was used, the reaction proceeded
smoothly at room temperature, but ee was low (Entry 2). Under the same reaction conditions,
Sonogashira coupling was examined using paracyclophane-based ligands (Entries 3-6). As a result,
monophosphine 2b realized the highest ee of 72% (Entry 4), which was higher than the previous best
result (57% ee) (Entry 1). Even when the amount of the catalyst was lowered from 30 mol% to 10 mol%,
comparable yield and ee were achieved (Entry 7).

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Table 4. Pd-catalyzed asymmetric Sonogashira coupling of 6a
PdCl2(MeCN)2 (30 mol%)
ligand (30 mol%)
CuI (30 mol%)
R
+
OMe
I
THF/i-Pr2NH (5/1), rt, 3 h
O
O
O
O
(4 equiv)
I
6a
7a
R
8aa
(R = p-methoxyphenyl)
Entry
Ligand
Yield / %
Ee / %
1a
TANIAPHOS
98
81
74
93
70
78
93
57
22
53
72
50
64
70
2
TANIAPHOS
3
2a
2b
3a
3b
2b
4
5
6
7b
a Cesium carbonate (4 equiv) was used as a base in
place of diisopropylamine and the reaction time was
6 h. b Less amounts of PdCl2(MeCN)2 (10 mol%), 2b
(10 mol%), and CuI (10 mol%) were used.
Substrate scope of alkynes and diiodoparacyclophanes was examined, and the enantiomeric excesses
under the previous optimal conditions were listed in the rightmost row for comparison (Table 5). A few
MeO-substituted arylalkynes 7b-7d were submitted to the reaction with paracyclophane 6a and the
corresponding dialkynylated products 8ab-8ad were obtained in excellent yield (Entries 1-3). Among
them, 2-ethynylanisole (7c) induced the highest enantioselectivity of 76% (Entry 2). Phenylacetylene (7e)
was also a good coupling partner (Entry 4). Propargyl ethers 7f and 7g could be used, but the yield was
low to moderate because of the formation of 1,3-diynes as by-products (Entries 5 and 6). In the reaction
of other diiodoparacyclophanes 6b-6e with alkyne 7a (Entries 7-10), 1,4-naphthylene-tethered
paracyclophane 6c was a preferable substrate and the highest ee of 90% was achieved, which is the
highest value among all previous results using TANIAPHOS as a chiral ligand.10c

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Table 5. Asymmetric Sonogashira coupling of various diiodoparacyclophanes and alkynes using 2b
Entry
Substrate
6a
R
Yield / %
97 (8ab)
94 (8ac)
95 (8ad)
80 (8ae)
34 (8af)
51 (8ag)
92 (8ba)
80 (8ca)
87 (8da)
81 (8ea)
Ee / %
55
Ee / %a
59
1
2
3-MeOC6H4 (7b)
2-MeOC6H4 (7c)
2,6-(MeO)2C6H3 (7d)
C6H5 (7e)
6a
76
69
3
6a
62
66
4
6a
79
56
5
6a
BnOCH2 (7f)
66
78
6
6a
MeOCH2 (7g)
79
79
7
6b
4-MeOC6H4 (7a)
4-MeOC6H4 (7a)
4-MeOC6H4 (7a)
4-MeOC6H4 (7a)
76
55
8
6c
90
54
9
6d
72
52
10
6e
68
58
a The result under the optimal reaction conditions using TANIAPHOS:
PdCl2(MeCN)2 (10 mol%), TANIAPHOS (10 mol%), CuI (10 mol%) Cs2CO3 (4
equiv) in THF at 25 °C.10c
Finally, we investigated enantioselective desymmetrization of tricarbonyl(!6-ortho-dichlorobenzene)-
chromium 9 by Suzuki-Miyaura coupling because planar chiral ligand, N,N-dimethyl-1-[2-
(diphenylphosphino)ferrocenyl]ethylamine (PPFA) realized good enantioselectivity in this reaction, but
toxic TlOH was used as a base.17 We examined the coupling of the chromium arene complex with
phenylboronic acid (10a) using much less toxic Na2CO3 as a base. According to the screening of
planar-chiral phosphines (Table 6, Entries 1-4), diphosphine 3b was optimal and high enantioselectivity
was achieved.18 The coupling of 9 with 4-methoxyphenylboronic acid (10b) also proceeded in high
enantioselectivity (Entry 5).

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Table 6. Asymmetric Suzuki-Miyaura coupling of tricarbonyl(!6-ortho-dichlorobenzene)chromium
Entry
Ligand
2a
Ar
Yield / %
59 (11a)
48 (11a)
58 (11a)
66 (11a)
59 (11b)
Ee / %
55
1
2
C6H5 (10a)
C6H5 (10a)
24
2b
3
C6H5 (10a)
59
3a
4
C6H5 (10a)
85
3b
5a
79
3b
4-MeOC6H4 (10b)
a The reaction time was 2 h.
In conclusion, a new family of [n]paracyclophane-based planar-chiral phosphines was synthesized by
enantioselective ortho-lithiation of 1,n-dioxa[n]paracyclophane using sec-butyllithium and (-)-sparteine.
Treatment of the chiral monolithiated- and dilithiated 1,n-dioxa[n]paracyclophane with a chlorophosphine
derivatives gave planar-chiral monophosphines and C2-symmetric diphosphines, respectively, with
excellent ee. These phosphines were used as chiral ligands in Ag-catalyzed allylation of imines and
Pd-catalyzed couplings. As a result, good to high enantioselectivities were achieved in the asymmetric
Sonogashira coupling of diiodoparacyclophanes possessing a flippable ansa chain (up to 90% ee) and
asymmetric desymmetrization of tricarbonyl(!6-ortho-dichlorobenzene)chromium by Suzuki-Miyaura
coupling (up to 85% ee).
EXPERIMENTAL
General. All reactions were examined under an argon atmosphere in oven-dried glassware with a
magnetic stirring bar. A hexane-cyclohexane solution of sec-butyllithium (1.0 M) was purchased from
Kanto Chemical Co., Inc. Dehydrated diethyl ether and tetrahydrofuran (THF) were purchased from
Wako Pure Chemical Industries Ltd. (Wako), and purified by passing thorough a purification system
(Glass Contour) before use.19 (-)-Sparteine was purchased from Tokyo Chemical Industry Co., Ltd. (TCI).
Other reagents were purchased from Wako, Kanto, TCI, or Aldrich and were used without further
purification. Flash column chromatography was performed with silica gel (Kanto Chemical Co., Inc. 60 N
40-50 "m). Preparative thin-layer chromatography (PTLC) was performed with silica gel-precoated glass
plates (Merck 60 GF254) prepared in our laboratory. Gel permeation chromatography (GPC) was

HETEROCYCLES, Vol. 88, No. 2, 2014
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performed on JAI LC-908. IR spectra were recorded with Horiba FT730 spectrophotometer. NMR spectra
were measured with JEOL AL-400 (400 MHz), JEOL ECS400 (400 MHz), JEOL ECX500 (500 MHz), or
JEOL Lambda 500 (500 MHz) using TMS as an internal standard and CDCl3 was used as a solvent.
High-resolution mass spectra (HRMS) were measured on a JEOL JMS-SX102A with FAB (Fast Atomic
Bombardment) method or JMS-T100CS with ESI (Electro Spray Ionization) method. Optical rotations
were measured with Jasco DIP-1000 polarimeter. Physical properties of phosphines 2a and 3b, and
Sonogashira-coupling products 8aa-8ag were omitted, because they were already listed in the precedent
report.10c,11
Typical Experimental Procedure of Enantioselective Monolithiation for the Synthesis of
Monophosphine 2 (Table 1). A cyclohexane-hexane solution of sec-butyllithium (1.0 M, 1.2 or 2.0 mL,
1.2 or 2.0 mmol) was added dropwise to an ether solution (5 mL) of a 1,n-dioxa[n]paracyclophane 1 (1.0
mmol) and (-)-sparteine (230 "L, 1.0 mmol) at -78 °C and the reaction mixture was stirred for 3 h at
-78 °C. To the mixture was added dropwise chlorodiarylphosphine (2 mmol) at -78 °C, and the reaction
mixture stirred for 2 h at room temperature. It was filtered through a short plug of silica gel with CH2Cl2
and the filtrate was evaporated under reduced pressure. The crude products were purified by flash column
chromatography (hexane/CH2Cl2= 3/1) to give the corresponding paracyclophane 2.
13-(Diphenylphosphino)-1,11-dioxa[11]paracyclophane (2b). White solid. Mp 110 °C; IR (CH2Cl2)
1
2925, 2854, 1473, 1456, 1194, 742, 696 cm-1; H NMR (500 MHz) # 0.67-0.79 (m, 1H), 0.79-1.08 (m,
8H), 1.10-1.23 (m, 1H), 1.35-1.47 (m, 1H), 1.50-1.67 (m, 2H), 1.81-1.93 (m, 1H), 3.87-3.96 (m, 1H),
13
3.99-4.07 (m, 1H), 4.20-4.334 (m, 2H), 6.32-6.37 (m, 1H), 7.00-7.07 (m, 2H), 7.26-7.40 (m, 10H); C
NMR (125 MHz) # 25.8, 26.0, 26.0, 26.2, 26.5, 27.9, 29.8, 71.7, 72.0 (d, J= 2.1 Hz), 119.8 (d, J= 2.1 Hz),
122.1, 125.2, 128.3 (d, J= 6.2 Hz), 128.4, 128.5 (d, J= 6.2 Hz), 128.9, 130.9 (d, J= 13.4 Hz), 133.1 (d,
J= 19.7 Hz), 134.5 (d, J= 20.7 Hz), 136.4 (d, J= 10.3 Hz), 137.1 (d, J= 11.3 Hz), 154.5, 156.6 (d, J=
16.6 Hz); 31P NMR (200 MHz) # -17.9; HRMS (FAB+) for M+ found m/z 418.2057, calcd for C27H31O2P:
418.2056. [!]26D 5.8 (c 1.21 CHCl3, 98% ee). Ee was determined by HPLC analysis using a chiral column
(Daicel Chiralpak IA: 4 x 250mm, 254nm UV detector, rt, eluent: 20% CH2Cl2 in hexane, flow rate: 0.5
mL/min, retention time: 9.1 min for major isomer and 9.8 min for minor isomer). The crystal data of 2b:
C27H31O2P, M=418.51, monoclinic, space group P21 (no. 4), a = 8.7764(3) Å, b = 12.7465(4) Å, c =
10.3739(3) Å, # = 98.110(2) °, V = 1148.91(6) Å3, T=173 K, Z=2, µ(Cu K$) 12.086 cm-1; number of
reflections measured: total 12,015 and unique 4026, R1=0.0490, wR2=0.1295, Flack parameter (Friedel
pairs=1823) 0.01(3). CCDC 953143.
13-(Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)-1,11-dioxa[11]paracyclophane (2c). White solid.
Mp 85 °C; IR (CH2Cl2) 2924, 1279, 1185, 1136, 899, 802, 682 cm-1; 1H NMR (400 MHz) ! 0.65-0.72 (m,

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1H), 0.84-0.97 (m, 5H), 0.98-1.06 (m, 1H), 1.07-1.13 (m, 1H), 1.19-1.34 (m, 1H), 1.39-1.43 (m, 1H),
1.58-1.67 (m, 3H), 1.72-1.84 (m, 1H), 3.95-3.99 (m, 1H), 4.09-4.13 (m, 1H), 4.22-4.31 (m, 2H),
6.28-6.30 (m, 1H), 7.11-7.18 (m, 2H), 7.68-7.74 (m, 4H), 7.91 (d, J= 15.9 Hz, 2H); 13C NMR (125 MHz)
! 25.7, 25.8, 26.1, 26.6, 27.8, 29.5, 72.1 (d, J= 14.4 Hz), 119.9, 121.7 (d, J= 8.5 Hz), 123.4, 124.1-124.7
(m), 126.1 (d, J= 14.2 Hz), 131.9-132.5 (m), 133.1 (d, J= 26.3 Hz), 133.6 (d, J= 25.2 Hz), 138.5 (d, J=
31
19
22.4 Hz), 139.8 (d, J= 22.4 Hz), 154.9, 156.6 (d, J= 20.3 Hz); P NMR (200 MHz) ! -12.2; F NMR
(470 MHz) ! -62.6, -62.9; HRMS (FAB+) for [M+H]+ found m/z 691.1627, calcd for C31H28O2F12P:
691.1630. ["]37 -28.5 (c 1.09 CHCl3, 98% ee). Ee was determined by HPLC analysis using a chiral
D
column (Daicel Chiralpak IA: 4 x 250 mm, 254 nm UV detector, rt, eluent: 20% CH2Cl2 in hexane, flow
rate: 0.5 mL/min, retention time: 6.0 min for major isomer and 8.3 min for minor isomer).
13-(Diphenylphosphinic)-1,11-dioxa[11](1,4)naphthalenophane (oxide of 2d). To a mixture of 1c and
2d in CH2Cl2-acetone (1/1, 0.5 mL), H2O2 (0.5 mL) was added and stirred for 1 h at room temperature.
The solvent was removed under reduced pressure. The residue was extracted with CH2Cl2 and the
combined organic layer was dried over Na2SO4. The solvent was removed under the reduced pressure and
the crude products were purified by PTLC (AcOEt) to give the oxide of 2d. White solid. Mp 57 °C; IR
1
(CH2Cl2) 3060, 1586, 1499, 1230, 1025, 728, 699 cm-1; H NMR (400 MHz) ! 0.26-0.29 (m, 3H),
0.60-0.63 (m, 3H), 0.77-0.82 (m, 3H), 0.88-0.90 (m, 1H), 1.19-1.24 (m, 1H), 1.34-1.39 (m, 1H),
1.70-1.76 (m, 1H), 1.80-1.86 (m, 1H), 4.17-4.28 (m, 2H), 4.31-4.40 (m, 2H), 6.98-7.02 (m, 1H),
7.45-7.47 (m, 4H), 7.51-7.53 (m, 3H), 7.58-7.60 (m, 1H), 7.71-7.78 (m, 4H), 8.12-8.17 (m, 1H),
13
8.24-8.28 (m, 1H); C NMR (125 MHz) ! 24.9, 25.9, 26.2, 26.3, 27.6, 29.4, 30.6, 72.4, 75.9, 115.6 (d,
J= 11.7 Hz), 119.8, 120.9, 122.4, 124.3, 126.4, 128.0, 128.3 (d, J= 15.6 Hz), 128.5 (d, J= 14.4. Hz),
31
130.5 (d, J= 12.7 Hz), 131.1, 131.5, 131.6, 131.7, 132.0 (d, J= 12.0 Hz), 133.0, 152.0, 154.6; P NMR
(200 MHz) ! 33.8; HRMS (FAB+) for [M+H]+ found m/z 485.2242, calcd for C31H34O3P: 485.2240.
["]34 -106.8 (c 1.58 CHCl3, 98% ee). Ee was determined by HPLC analysis using a chiral column
D
(Daicel Chiralpak IC: 4 x 250 mm, 254 nm UV detector, rt, eluent: 50% 2-propanol in hexane, flow rate:
1.0 mL/min, retention time: 5.7 min for major isomer and 7.0 min for minor isomer).
Typical Experimental Procedure of Enantioselective Dilithiation for the Synthesis of Diphosphine 3
(Table 2). A cyclohexane-hexane solution of sec-butyllithium (1.0 M, 2.0 mL, 2.0 mmol) was added
dropwise to an ether solution (5 mL) of a 1,n-dioxa[n]paracyclophane 1 (1 mmol) and (-)-sparteine (275
"L, 1.2 mmol) at -78 °C and the reaction mixture was stirred for 3 h at -78 °C. Then A
cyclohexane-hexane solution of sec-butyllithium (1.0 M, 2.0 mL, 2.0 mmol) was added dropwise and the
resulting mixture was stirred for 12 h at -20 °C. To the mixture was added dropwise
chlorodiphenylphosphine (6 mmol) at -78 °C, and the reaction mixture was stirred for 2 h at room
temperature. It was filtered through a short plug of silica gel with CH2Cl2 and the filtrate was evaporated

HETEROCYCLES, Vol. 88, No. 2, 2014
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under reduced pressure. The crude products were purified by flash column chromatography
(hexane/CH2Cl2 = 5/1) to give the corresponding paracyclophane 3.
12,15-Bis(diphenylphosphino)-1,10-dioxa[10]paracyclophane (3a). White solid. Mp 218 °C; IR
1
(CH2Cl2) 2926, 2854, 1465, 1433, 1384, 1348, 1331, 1265, 1244, 743, 696, 416 cm-1; H NMR (400
MHz) ! 0.49-0.55 (m, 2H), 0.80-0.86 (m, 2H), 1.03-1.04 (m, 4H), 1.50-1.51 (m, 2H), 1.52-1.53 (m, 2H),
13
3.73-3.77 (m, 2H), 4.08-4.13 (m, 2H), 6.28-6.30 (m, 2H), 7.25-7.36 (m, 20H); C NMR (125 MHz) !
24.0, 26.6, 27.5 (d, J= 3.9 Hz), 72.3, 128.0 (d, J=7.2 Hz), 128.5 (d, J= 7.5 Hz), 129.1, 133.13, 134.6 (d,
J= 19.9 Hz), 136.9, 155.1; 31P NMR (200 MHz) ! -12.2; HRMS (FAB+) for [M+H]+ found m/z 589.2446,
calcd for C38H39O2P2: 589.2420. ["]37 -78.6 (c 0.1 CHCl3, 97% ee). Ee was determined by HPLC
D
analysis of the oxidized product using a chiral column (Daicel Chiralpak IA: 4 x 250 mm, 254 nm UV
detector, rt, eluent: 70% 2-propanol in hexane, flow rate: 1.0 mL/min, retention time: 7.5 min for major
isomer and 12.9 min for minor isomer).
13,16-Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)-1,11-dioxa[11]paracyclophane (3c). White
1
solid. Mp 210 °C; IR (CH2Cl2) 2923, 1470, 1278, 1177, 1096, 898, 765 cm-1; H NMR (400 MHz) !
0.71-0.75 (m, 2H), 0.91-1.12 (m, 6H), 1.38-1.43 (m, 2H), 1.53-1.62 (m, 2H), 1.67-1.72 (m, 2H),
3.81-3.87 (m, 2H), 4.11-4.17 (m, 2H), 6.31-6.33 (m, 2H), 7.64-7.65 (m, 4H), 7.72-7.74 (m, 4H), 7.93 (d,
13
J= 5.5 Hz, 4H); C NMR (125 MHz) ! 25.5 (d, J= 4.8 Hz), 26.5, 27.9, 28.9, 72.2, 121.6 (d, J= 2.4 Hz),
122.8, 123.6-123.9 (m), 124.3, 127.0, 130.0 (d, J= 16.8 Hz), 133.0-133.5 (m), 137.2 (d, J= 21.5 Hz),
139.0 (d, J= 23.5 Hz), 156.4 (d, J= 20.3 Hz); 31P NMR (200 MHz) ! -11.4; 19F NMR (470 MHz) ! -63.1,
-62.9; HRMS (FAB+) for [M+H]+ found m/z 1147.1578, calcd for C47H33F24O2P2: 1147.1567. ["]36D -82.5
(c 0.465 CHCl3, 98% ee). Ee was determined by HPLC analysis of the oxidized product using a chiral
column (Doubly-arrayed Daicel Chiralcel IC and IC-3: 4 x 250 mm, 254 nm UV detector, rt, eluent: 50%
CH2Cl2 in hexane, flow rate: 1.0 mL/min, retention time: 6.1 min for major isomer and 6.8 min for minor
isomer).
Typical Experimental Procedure for Enantioselective Allylation of Imines 4b Using Phosphine
Ligands (Table 3, Entries 5-8). A MeOH solution (1.0 mL) of AgF (6.3 mg, 0.05 mmol) and
planar-chiral phosphine (0.05 mmol) was stirred for 10 min and then MeOH was excluded under vacuum
for 1 h. After cooling of the resulting white solid to -78 °C, MeOH (20 µL, 0.5 mmol) and THF (1.5 mL)
were added and the mixture was stirred for 10 min. To the resulting clear solution, allyltrimethoxysilane
(1.0 mmol) and imine 4b (91.0 mg, 0.50 mmol) were added successively at -78 °C and the mixture was
stirred at -78 °C for 12 h. The reaction mixture was passed through a short silica gel column using Et2O as
an eluent. The solvent was excluded under the reduced pressure, and the crude products were purified by
thin-layer chromatography to give allylated product 5b.20

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HETEROCYCLES, Vol. 88, No. 2, 2014
Typical Experimental Procedure for Enantioselective Sonogashira Coupling (Table 5). A THF
solution (0.2 mL) of PdCl2(MeCN)2 (3.9 mg, 0.015 mmol) and 2b (10.2 mg, 0.015 mmol) was stirred for
10 min. To the solution were added diiodoparacyclophane 6 (0.05 mmol) in THF (0.8 mL), i-Pr2NH (0.2
mL), alkyne 7 (0.2 mmol) and CuI (2.9 mg, 0.015 mmol) in order. The resulting mixture was stirred at
room temperature. After the reaction was complete, H2O was added to the reaction mixture, and organic
materials were extracted with AcOEt. The organic layer was washed with brine and dried with Na2SO4.
The solvent was removed under reduced pressure, and the crude products were purified by thin-layer
chromatography to give dialkynylated product 8.
22,25-Bis{2-(4-methoxyphenyl)ethynyl}-1,20-dioxa[9.9]paracyclophane (8ba). Yellow oil; IR
1
(CH2Cl2) 2929, 2854, 2227, 1516, 1248, 1031, 831; H NMR ! 1.12-1.55 (m, 18H), 1.63-1.77 (m, 4H),
1.84-2.01 (m, 2H), 2.36-2.50 (m, 4H), 3.83 (s, 6H), 3.92-4.02 (m, 2H), 4.06-4.19 (m, 2H), 6.88 (d, J= 9.0
Hz, 4H), 6.95 (s, 4H), 6.99 (s, 2H), 7.47 (d, J= 9.0 Hz, 4H); 13C NMR ! 24.7, 27.1, 27.8, 28.0, 28.3, 30.7,
35.0, 55.3, 66.4, 84.8, 94.7, 113.9, 114.1, 115.7, 116.9, 128.3, 133.0, 139.7, 153.3, 159.5; HRMS (FAB+)
for M+ found m/z 668.3848, calcd for C46H52O4: 668. 3860. ["]12 -23.9 (c 1.62 CHCl3, 55% ee). Ee was
D
determined by HPLC analysis using a chiral column (Daicel Chiralpak IA: 4 x 250 mm, 254 nm UV
detector, rt, eluent: 30% CH2Cl2 in hexane, flow rate: 1.0 mL/min, retention time: 7.5 min for major
isomer and 13.1 min for minor isomer).
24,27-Bis{2-(4-methoxyphenyl)ethynyl}-1,22-dioxa[7](1,4)naphthalene[7]paracyclophane
(8ca).
1
Yellow oil; H NMR ! 1.17-1.32 (m, 4H) 1.33-1.49 (m, 2H), 1.59-1.79 (m, 6H), 1.81-1.96 (m, 2H),
1.97-2.13 (m, 2H), 2.74-2.92 (m, 2H), 3.02-3.18 (m, 2H), 3.83 (s, 6H), 3.96-4.22 (m, 4H), 6.28 (s, 2H),
6.89 (d, J= 8.8 Hz, 4H), 6.98 (s, 2H), 7.40 (dd, J= 3.3 Hz, 6.6 Hz, 2H), 7.50 (d, J= 8.8 Hz, 4H), 7.98 (dd,
J= 3.3 Hz, 6.6 Hz, 2H); 13C NMR ! 23.1, 25.6, 27.7, 28.5, 30.6, 55.4, 67.7, 84.9, 95.0, 114.1, 114.6, 115.8,
117.4, 124.7, 124.8, 126.4, 132.2, 133.1, 135.5, 153.0, 159.7; HRMS (FAB+) for [M+Na]+ found m/z
685.3284, calcd for C46H46O4Na: 685.3288. ["]28 16.5 (c 1.38 CHCl3, 54% ee). Ee was determined by
D
HPLC analysis using a chiral column (Daicel Chiralpak IA: 4 x 250 mm, 254 nm UV detector, rt, eluent:
30% CH2Cl2 in hexane, flow rate: 1.0 mL/min, retention time: 5.5 min for major isomer and 8.4 min for
minor isomer).
20,23-Bis{2-(4-methoxyphenyl)ethynyl}-1,18-dioxa[18]paracyclophane (8da). Pale yellow solid. Mp
1
134 °C; IR (CH2Cl2) 2925, 2852, 2208, 1604, 1515, 1463, 1248, 1172, 1032, 831 cm-1; H NMR #
0.99-1.14 (m, 8H) 1.14-1.28 (m, 8H), 1.28-1.47 (m, 6H), 1.60-1.77 (m, 4H), 1.80-1.96 (m, 2H), 3.83 (s,
6H), 4.05-4.16 (m, 2H), 4.16-4.27 (m, 2H), 6.87 (d, J= 8.7 Hz, 4H), 7.00 (s, 2H), 7.47 (d, J= 8.7 Hz, 4H);
13C NMR # 24.1, 26.9, 27.7, 28.0, 28.2, 28.7, 29.4, 55.2, 68.6, 84.8, 94.6, 113.9, 114.3, 115.8, 117.6,
133.0, 153.0, 159.6; HRMS (FAB+) for M+ found m/z 592.3550. calcd for C40H48O4: 592.3547. [!]26
D
-34.0 (c 1.55 CHCl3, 54% ee). Ee was determined by HPLC analysis using a chiral column (Daicel

HETEROCYCLES, Vol. 88, No. 2, 2014
1367
Chiralpak IA: 4 x 250 mm, 254 nm UV detector, rt, eluent: 30% CH2Cl2 in hexane, flow rate: 1.0 mL/min,
retention time: 7.8 min for major isomer and 11.9 min for minor isomer).
22,25-Bis{2-(4-methoxyphenyl)ethynyl}-1,4,7,14,17,20-hexaoxa-[7.7]paracyclophane (8ea). Yellow
solid. Mp 95 °C; IR (CH2Cl2) 2927, 2862, 2210, 1604, 1515, 1463, 1248, 1209, 1062, 1029, 833 cm-1; 1H
NMR ! 3.72-3.80 (m, 2H), 3.83 (s, 6H), 3.83-3.92 (m, 2H), 3.92-4.10 (m, 8H), 4.18-4.25 (m, 4H), 6.58 (s,
13
4H), 6.88 (d, J= 9.1 Hz, 4H), 6.89 (s, 2H), 7.43 (d, J= 9.1 Hz, 4H); C NMR ! 55.3, 69.1, 69.5, 70.0,
70.0, 85.0, 94.5, 113.8, 114.0, 115.6, 116.4, 117.4, 132.9, 152.2, 152.9, 159.6; HRMS (FAB+) for M+
found m/z 620.2394, calcd for C38H36O8: 620.2405. ["]13 10.5 (c 1.41 CHCl3, 58% ee). Ee was
D
determined by HPLC analysis using a chiral column (Daicel Chiralpak IA: 4 x 250 mm, 254 nm UV
detector, rt, eluent: 50% CH2Cl2 in hexane, flow rate: 1.0 mL/min, retention time: 5.1 min for major
isomer and 6.1 min for minor isomer).
Typical Procedure for Enantioselective Suzuki Coupling (Table 6). A MeOH solution (0.5 mL) of
PdCl2(MeCN)2 (3.9 mg, 0.015 mmol) and phosphine ligand (0.015 mmol) was stirred for 30 min. To the
solution were added chromium complex 9 (14.2 mg, 0.05 mmol) and arylboronic acid 10 (0.1 mmol) in
MeOH (0.5 mL) and Na2CO3 (10.6 mg, 0.1 mmol) in water (0.1 mL) in order. The resulting mixture was
stirred at room temperature. After the reaction was complete, it was filtered through a short plug of silica
gel with Et2O as an eluent and the filtrate was evaporated under reduced pressure. The crude products
were purified by thin-layer chromatography (hexane/EtOAc = 5/1) to give mono-arylated product 11.
(1S,2R)-Tricarbonyl(2-phenylchlorobenzene)chromium (11a). The physical properties of this
compound were consistent with those in the literature.11b
Tricarbonyl(2-(4-methoxyphenyl)chlorobenzene)chromium (11b). Yellow oil; IR (CH2Cl2) 1970, 1893,
1338, 1249, 1179 cm-1; 1H NMR # 3.85 (s, 3H), 5.13 (dd, J= 6.0, 6.0 Hz, 1H), 5.45-5.54 (m, 2H), 5.62 (d,
J= 6.0 Hz, 1H), 6.94 (d, J= 8.2 Hz, 2H), 7.45 (d, J= 8.2 Hz, 2H); 13C NMR # 55.3, 87.8, 90.6, 93.2, 96.1,
110.3, 113.4, 113.6, 126.9, 131.7, 160.1, 231.7; HRMS (FAB+) for M+ found m/z 353.9744, calcd for
C16H11O4ClCr: 353.9745; [!]27D 19.6 (c 1.44 CHCl3, 79% ee). Ee was determined by HPLC analysis using
a chiral column (Doubly-arrayed Daicel Chiralpak AD-H: 4 x 250 mm, 254 nm UV detector, rt, eluent:
2% 2-propanol in hexane, flow rate: 1.0 mL/min, retention time: 9 min for minor isomer and 10 min for
major isomer).
ACKNOWLEDGEMENTS
K. Kanda is grateful to the Japan Society for the Promotion of Science for the fellowship support. This
work was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture,

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Sports, Science and Technology, Japan (No. 23655091). We also thank Asahi Glass Foundation, the
Global COE program ‘Center for Practice Chemical Wisdom’ by MEXT, and ACT-C. We also express
our thanks to Dr. Takashi Otani (Waseda Univ.) for general support for this project.
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14. No racemization of 2a in solid state was observed at room temperature for about 8 months.

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